Metabolism The Adaptor Protein p 66 Shc Inhibits mTOR-Dependent Anabolic `

@inproceedings{Zheng2014MetabolismTA,
  title={Metabolism The Adaptor Protein p 66 Shc Inhibits mTOR-Dependent Anabolic `},
  author={Yong Zheng and David M. Sabatini and J. W. Dennis and Tony J. Pawson and Birsoy and Judy Pawling and Mar{\'i}a E Frigolet and Huogen Lu and Ivan George Fantus and Adri{\'a}n and M. A. Soliman and Anas M. Abdel Rahman and Dudley W Lamming and Kivanç},
  year={2014}
}
Metabolism The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic`This information is current as of 24 March 2014. Adaptor proteins link surface receptors to intracellular signaling pathways and potentially control the way cells respond to nutrient availability. Mice deficient in p66Shc, the most recently evolved isoform of the Shc1 adaptor proteins and a mediator of receptor tyrosine kinase signaling, display resistance to diabetes and obesity. Using quantitative mass spectrometry, we… CONTINUE READING