Metabolism-Independent Sugar Sensing in Central Orexin Neurons

@article{Gonzlez2008MetabolismIndependentSS,
  title={Metabolism-Independent Sugar Sensing in Central Orexin Neurons},
  author={J. Antonio Gonz{\'a}lez and Lise Torp Jensen and Lars Fugger and Denis Burdakov},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2569 - 2576}
}
OBJECTIVE Glucose sensing by specialized neurons of the hypothalamus is vital for normal energy balance. In many glucose-activated neurons, glucose metabolism is considered a critical step in glucose sensing, but whether glucose-inhibited neurons follow the same strategy is unclear. Orexin/hypocretin neurons of the lateral hypothalamus are widely projecting glucose-inhibited cells essential for normal cognitive arousal and feeding behavior. Here, we used different sugars, energy metabolites… CONTINUE READING

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