Metabolism: FTO-associated obesity risk is linked to brain food responses via modulation of ghrelin levels

Abstract

In cell-based assays, FTO overexpression resulted in higher ghrelin mRNA expression and total levels of active ghrelin compared with controls. This finding was paralleled by reduced methylation of ghrelin mRNA owing to demethylation catalysed by FTO, providing a direct link between FTO risk alleles and ghrelin action. The authors suggest that the FTO genotype alters brain responsivity to circulating ghrelin levels. The identified link could be the basis for “strategies aimed at modulating the ghrelin system to help prevent people with the obesity-risk FTO variant from becoming overweight, and also help overweight or obese people lose weight,” concludes Batterham.

DOI: 10.1038/nrendo.2013.155

Cite this paper

@article{Eissing2013MetabolismFO, title={Metabolism: FTO-associated obesity risk is linked to brain food responses via modulation of ghrelin levels}, author={Leah Eissing}, journal={Nature Reviews Endocrinology}, year={2013}, volume={9}, pages={564-564} }