Metabolism: Partial leptin deficiency and human adiposity

  title={Metabolism: Partial leptin deficiency and human adiposity},
  author={I. Farooqi and J. Keogh and Sri Kamath and S. Jones and W. Gibson and R. Trussell and S. Jebb and G. Lip and S. O'rahilly},
  • I. Farooqi, J. Keogh, +6 authors S. O'rahilly
  • Published 2001
  • Biology, Medicine
  • Nature
  • The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can… CONTINUE READING
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