Metabolism, Excretion, and Pharmacokinetics of [14C]Tigecycline, a First-In-Class Glycylcycline Antibiotic, after Intravenous Infusion to Healthy Male Subjects

@article{Hoffmann2007MetabolismEA,
  title={Metabolism, Excretion, and Pharmacokinetics of [14C]Tigecycline, a First-In-Class Glycylcycline Antibiotic, after Intravenous Infusion to Healthy Male Subjects},
  author={Matthew Hoffmann and William Demaio and R. A. Juste Jord{\'a}n and Rasmy E. Talaat and Dawn Harper and John L. Speth and Joann Scatina},
  journal={Drug Metabolism and Disposition},
  year={2007},
  volume={35},
  pages={1543 - 1553}
}
Tigecycline, a novel, first-in-class glycylcycline antibiotic, has been approved for the treatment of complicated intra-abdominal infections and complicated skin and skin structure infections. The pharmacokinetics, metabolism, and excretion of [14C]tigecycline were examined in healthy male volunteers. Tigecycline has been shown to bind to bone; thus, to minimize the amount of radioactivity binding to bone and to maximize the recovery of radioactivity, tigecycline was administered intravenously… Expand
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