Metabolism, Cell Surface Organization, and Disease

@article{Dennis2009MetabolismCS,
  title={Metabolism, Cell Surface Organization, and Disease},
  author={J. W. Dennis and Ivan Robert Nabi and Michael Demetriou},
  journal={Cell},
  year={2009},
  volume={139},
  pages={1229-1241}
}
Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and, in this capacity, acts upstream of signaling and gene expression. The structure and number of N-glycans per protein molecule cooperate to regulate lectin binding and thereby the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 132 extracted citations

Plasma N-glycans in colorectal cancer risk

Scientific Reports • 2018
View 4 Excerpts
Highly Influenced

N-Acetylglucosamine Functions in Cell Signaling

Scientifica • 2012
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 123 references

Similar Papers

Loading similar papers…