Metabolism, Cell Surface Organization, and Disease

  title={Metabolism, Cell Surface Organization, and Disease},
  author={J. W. Dennis and Ivan Robert Nabi and Michael Demetriou},
Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and, in this capacity, acts upstream of signaling and gene expression. The structure and number of N-glycans per protein molecule cooperate to regulate lectin binding and thereby the… CONTINUE READING


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