Metabolically independent and accurately adjustable Aspergillus sp. expression system.

@article{Pachlinger2005MetabolicallyIA,
  title={Metabolically independent and accurately adjustable Aspergillus sp. expression system.},
  author={Robert Pachlinger and Rudolf Mitterbauer and Gerhard Adam and Joseph Tunick Strauss},
  journal={Applied and environmental microbiology},
  year={2005},
  volume={71 2},
  pages={
          672-8
        }
}
Filamentous fungi are well-established expression hosts often used to produce extracellular proteins of use in the food and pharmaceutical industries. The expression systems presently used in Aspergillus species rely on either strong constitutive promoters, e.g., that for glyceraldehyde-3-phosphate dehydrogenase, or inducible systems derived from metabolic pathways, e.g., glaA (glucoamylase) or alc (alcohol dehydrogenase). We describe for Aspergillus nidulans and Aspergillus niger a novel… CONTINUE READING

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