Metabolic tracking of isoflavones in soybean products and biosamples from healthy adults after fermented soybean consumption.

  title={Metabolic tracking of isoflavones in soybean products and biosamples from healthy adults after fermented soybean consumption.},
  author={Hwan-Hee Jang and Hwayoung Noh and Heon-Woong Kim and Su-Yeon Cho and Hyeon-Jeong Kim and Seon Hye Lee and Sung-Hyen Lee and Marc J Gunter and Pietro Ferrari and Augustin Scalbert and Heinz Freisling and Jung-Bong Kim and Jeong-sook Choe and Oran Kwon},
  journal={Food chemistry},
  • Hwan-Hee Jang, Hwayoung Noh, +11 authors O. Kwon
  • Published 2020
  • Medicine, Chemistry
  • Food chemistry
Fermentation may enhance the nutritional properties of foods by increasing metabolite bioactivity or bioavailability. This study explored the effect of fermentation on isoflavone bioavailability and metabolism. Isoflavone metabolites were tracked in foods and biospecimens of healthy adults after fermented soybean (FS) or non-fermented soybean (NFS) consumption in a randomized, controlled, crossover intervention study. The change in soybean isoflavones caused by fermentation resulted in faster… Expand
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Bioconversion pathways and metabolic profile of daidzin by human intestinal bacteria using UPLC–Q-TOF/MS
Gut bacteria play a crucial role in the biotransformation of dietary isoflavonoids, which may affect the pharmacological effects of these bioactive compounds in the host. In this study, 67Expand
In Vitro Antibacterial Effect of the Methanolic Extract of the Korean Soybean Fermented Product Doenjang against Staphylococcus aureus
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  • Saeed Hamid Saeed Omer, YUAN Yanzhi, LI Gaoqiang, LIU Yongli, Gao Wenlong, R. A. Bhat
  • Biology
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Bioavailability of isoflavones after ingestion of soy beverages in healthy adults.
It is demonstrated that the is oflavone aglycones of soymilk were absorbed faster and in greater amounts than their glucosides in healthy adults and that the metabolism of isoflavones might be affected by the type ofSoymilk consumed. Expand
Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria
A modest dosage ranging from 20 to 30 mg/d may provide the most bioavailable source of isoflavone, regardless of whether it is via an aglycone-rich fermented soya milk or a glucoside-rich soya Milk. Expand
Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice
CGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women and OVX mice appear to show lower is oflavoneBioavailability than mice in the sham group. Expand
Changes in Isoflavone Compositions of Soybean Foods during Cooking Process
We evaluated the concentration and distribution of isoflavones in a total of 50 samples of soybean foods consumed daily in Japan by high-performance liquid chromatography (HPLC). A hierarchicalExpand
The Key Importance of Soy Isoflavone Bioavailability to Understanding Health Benefits
The importance of metabolism of the parent soy isoflavones and the critical role of gut microbiota on the bioavailability of these compounds and their metabolites is highlighted. Expand
Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women.
Previous hydrolysis of glycosides to aglycones does not enhance the bioavailability of isoflavones in humans, and the ratios of individual isOflavones to one another were not conserved from food to plasma to urine, indicating that the individual is oflavones do not have the same absorptions and body retentions. Expand
The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food products.
  • S. Barnes
  • Biology, Medicine
  • Lymphatic research and biology
  • 2010
Isoflavones and their metabolites are well absorbed and undergo an enterohepatic circulation, which may explain the much lower incidence of hormonally-dependent breast cancer in Asian populations compared to Americans and Europeans. Expand
Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.
Differences in the pharmacokinetics of isoflavone glycosides compared with their respective beta-glycosides are demonstrated and indicate a need for improvement in quality assurance and standardization of such products. Expand
Review of the Factors Affecting Bioavailability of Soy Isoflavones in Humans
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Glucuronides are the main isoflavone metabolites in women.
These studies showed that about one fifth of circulating is oflavones are aglycones, and Concentrations of isoflavones chosen for in vitro studies should take this into account. Expand