Metabolic systems maintain stable non-equilibrium via thermodynamic buffering.

  title={Metabolic systems maintain stable non-equilibrium via thermodynamic buffering.},
  author={Abir U. Igamberdiev and Leszek A. Kleczkowski},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={31 10},
Here, we analyze how the set of nucleotides in the cell is equilibrated and how this generates simple rules that help the cell to organize itself via maintenance of a stable non-equilibrium state. A major mechanism operating to achieve this state is thermodynamic buffering via high activities of equilibrating enzymes such as adenylate kinase. Under stable non-equilibrium, the ratios of free and Mg-bound adenylates, Mg(2+) and membrane potentials are interdependent and can be computed. The… CONTINUE READING
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