Metabolic syndrome meets osteoarthritis

@article{Zhuo2012MetabolicSM,
  title={Metabolic syndrome meets osteoarthritis},
  author={Qi Zhuo and Wei Yang and Jiying Chen and Yan Wang},
  journal={Nature Reviews Rheumatology},
  year={2012},
  volume={8},
  pages={729-737}
}
Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links have been discovered between this phenotype and metabolic syndrome (MetS)—both with individual MetS components and with MetS as a whole. Hypertension associates with OA through subchondral ischaemia, which can compromise nutrient exchange into articular cartilage and trigger bone remodelling. Ectopic lipid deposition in chondrocytes induced by dyslipidemia might initiate OA development, exacerbated by… CONTINUE READING
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