Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets.

@article{Romeo2012MetabolicSI,
  title={Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets.},
  author={Giulio R. Romeo and Jongsoon Lee and Steven E. Shoelson},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 8},
  pages={
          1771-6
        }
}
Obesity and its comorbidities, including type 2 diabetes mellitus and cardiovascular disease, are associated with a state of chronic low-grade inflammation that can be detected both systemically and within specific tissues. Areas of active investigation focus on the molecular bases of metabolic inflammation and potential pathogenic roles in insulin resistance, diabetes, and cardiovascular disease. An increased accumulation of macrophages occurring in obese adipose tissue has emerged as a key… CONTINUE READING

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