Metabolic studies with nonnutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate.

@article{Spillane1979MetabolicSW,
  title={Metabolic studies with nonnutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate.},
  author={William J. Spillane and Geoffrey A. Benson and G McGlinchey},
  journal={Journal of pharmaceutical sciences},
  year={1979},
  volume={68 3},
  pages={
          372-4
        }
}
The nonnutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate were fed separately to female Wistar albino rats, and the urine was examined for the possible metabolites cyclooctylamine, cyclooctanone, cyclooctanol, 4-methylcyclohexylamine, 4-methylcyclohexanone, and cis- and trans-4-methylcyclohexanols. The average percent conversions to cyclooctylamine, cyclooctanone, and cyclooctanol were 0.127, 0.08, and 0.092, respectively. The average percent conversions to 4… 
View on PubMed
doi.org
3 Citations

3 Citations

Toxicological aspects of cyclamate and cyclohexylamine.

This review of the published and unpublished literature on cyclamate attempts to evaluate the carcinogenicity question and other important aspects of the toxicity of cyclamate and cyclohexylamine, including their effects on various organ systems, their genotoxic potential, and their effect on reproduction.

Ketones of Six to Thirteen Carbons

Ketones of carbon number 6–13 are important commercial and industrial materials. Their primary use is as solvents in numerous products and industrial applications. Owing to their volatility,…

Chapter 32. Nonnutritive Sweeteners. The Search for Sucrose Mimics.

References

SHOWING 1-7 OF 7 REFERENCES

Metabolic studies of the nonnutritive sweeteners cyclopentylmethylsulfamate and cyclopentylsulfamate: determination of metabolites in rat urine.

The nonnutritive sweetener sodium cyclopentylmethyl-sulfamate was fed to Wistar albino rats and a decrease in the level of metabolites occurred after the first 3 days, with the lowest conversion to amine observed observed.

Determination of the nonnutritive sweetener sodium cyclopentylsulfamate and three of its metabolites, cyclopentylamine, cyclopentanone, and cyclopentanol, in urine of rats and rabbits.

The nonnutritive sweetener sodium cyclopentylsulfamate was fed to Wistar albino rats and New Zealand White rabbits and Assayed by hydrolysis in acidified dioxane-water and subsequent measurement of the absorbance of the product formed by the liberated amine with p-benzoquinone.

Metabolic studies with the nonnutritive sweetener cycloheptylsulfamate.

The nonnutritive sweetener cycloheptylsulfamate was administered orally to rabbits and rats. The urine of each species was separately collected for 3 days and examined for the metabolites…

Cycloalkylsulfaminsäuren und ihre Salze

SummarySeveral cycloalkylaulfamic acids and their salts, N,N′-dicycloalkylsulfamides, and dinitrophenylamines were synthesized from cycloalkylamines. Salts of the unsubstituted cycloalkylsulfamic…

Structure-activity studies on sulfamate sweeteners.

The structure-activity relationships governing sulfamate sweeteners are reviewed, and the B center of the Shallenberger A-H,B theory of sweetness is best regarded as being -SO3- rather than -SO2- for sulfamates.

Spectrophotometric microdetermination of amines and sulfamates with 1,4-Benzoquinone.

Gas chromatographic determination of cyclic amines, ketones and alcohols, possible metabolites of sweet sulphamates.