Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+.

@article{Wu1988MetabolicSO,
  title={Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+.},
  author={E Y Wu and T Shinka and P S Caldera-Munoz and Hajime Yoshizumi and Anthony J. Trevor and Neal Castagnoli},
  journal={Chemical research in toxicology},
  year={1988},
  volume={1 3},
  pages={186-94}
}
The metabolic fates of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its two-electron oxidation product, the 1-methyl-4-phenyl-2,3-dihydropyridinium species (MPDP+), have been examined in mouse brain and liver tissue fractions. Incubations of MPTP (50 microM and 1 mM) with mouse brain preparations result in the expected MAO B catalyzed formation of MPDP+. The four-electron oxidation product, the 1-methyl-4-phenyl-pyridinium species (MPP+), was the only other… CONTINUE READING

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