Metabolic studies of purine metabolism in the pig during the oral administration of guanine and allopurinol.

@article{Simmonds1973MetabolicSO,
  title={Metabolic studies of purine metabolism in the pig during the oral administration of guanine and allopurinol.},
  author={H. Simmonds and P. Hatfield and J. Cameron and A. S. Jones and A. Cadenhead},
  journal={Biochemical pharmacology},
  year={1973},
  volume={22 20},
  pages={
          2537-51
        }
}
Abstract (1) Allopurinol and guanine, both separately and together, were fed over varying periods to diiferent groups of large white/landrace cross pigs. Although allantoin and not uric acid represented the end point of purine metabolism in this species, total urinary purine excretion approximated that of a man of equivalent weight on a purine-free diet. No abnormality in the handling of guanine was found, up to 50 per cent of an exogenous load being absorbed, metabolized and rapidly excreted… Expand
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Dietary feedback regulation of purine and pyrimidine biosynthesis in man.
Differential absorption of purine nucleotides, nucleosides and bases.
Metabolism of intravenous adenine in the pig.
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