Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes

@article{Geldof2016MetabolicSO,
  title={Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes},
  author={Lore Geldof and L. Lootens and Lieselot Decroix and F. Botr{\`e} and P. V. Eenoo},
  journal={Steroids},
  year={2016},
  volume={107},
  pages={139-148}
}
  • Lore Geldof, L. Lootens, +2 authors P. V. Eenoo
  • Published 2016
  • Chemistry, Medicine
  • Steroids
  • Anabolic androgenic steroids are prohibited by the World Anti-Doping Agency because of their adverse health and performance enhancing effects. Effective control of their misuse by detection in urine requires knowledge about their metabolism. In case of designer steroids, ethical objections limit the use of human volunteers to perform excretion studies. Therefore the suitability of alternative models needs to be investigated. In this study pooled human liver microsomes (HLM) and an uPA(+/+)-SCID… CONTINUE READING
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