Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

@article{Hayashi2000MetabolicSA,
  title={Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.},
  author={Takuma Hayashi and Michael F. Hirshman and Nobuharu Fujii and Susan Amy Habinowski and Lee Alan Witters and Laurie J Goodyear},
  journal={Diabetes},
  year={2000},
  volume={49 4},
  pages={527-31}
}
5'AMP-activated protein kinase (AMPK) can be activated in response to cellular fuel depletion and leads to switching off ATP-consuming pathways and switching on ATP-regenerating pathways in many cell types. We have hypothesized that AMPK is a central mediator of insulin-independent glucose transport, which enables fuel-depleted muscle cells to take up glucose for ATP regeneration under conditions of metabolic stress. To test this hypothesis, rat epitrochlearis muscles were isolated and… CONTINUE READING
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