Metabolic strategies for the degradation of the neuromodulator agmatine in mammals.

@article{Bentez2018MetabolicSF,
  title={Metabolic strategies for the degradation of the neuromodulator agmatine in mammals.},
  author={Jos{\'e} Alberto Ben{\'i}tez and David Alejandro Garcia and Nicol Romero and Arlette Gonz{\'a}lez and Jos{\'e} Mart{\'i}nez-Oyanedel and Maximiliano Figueroa and M{\'o}nica Salas and Vasthi L{\'o}pez and Mar{\'i}a de Los {\'A}ngeles Garc{\'i}a-Robles and Peter Ronald Dodd and Gerhard Schenk and Nelson Carvajal and Elena A. Uribe},
  journal={Metabolism: clinical and experimental},
  year={2018},
  volume={81},
  pages={35-44}
}
Agmatine (1-amino-4-guanidinobutane), a precursor for polyamine biosynthesis, has been identified as an important neuromodulator with anticonvulsant, antineurotoxic and antidepressant actions in the brain. In this context it has emerged as an important mediator of addiction/satiety pathways associated with alcohol misuse. Consequently, the regulation of the activity of key enzymes in agmatine metabolism is an attractive strategy to combat alcoholism and related addiction disorders. Agmatine… CONTINUE READING