Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn.

@article{Wang1999MetabolicSO,
  title={Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn.},
  author={Zichun Wang and Askale Mathias and Medha Gautam and Zach W. Hall},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 6},
  pages={1998-2007}
}
Although the metabolic half-life of muscle endplate acetylcholine receptor (AChR) changes during development and after denervation in the adult, little is known about the molecular mechanisms that influence receptor stability. We have investigated the effect on AChR turnover of its interaction with rapsyn, a 43 kDa peripheral membrane protein that is closely associated with the AChR in muscle cells and is required for its clustering at endplates. Both in transfected COS cells and in cultured… CONTINUE READING

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