Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn.

  title={Metabolic stabilization of muscle nicotinic acetylcholine receptor by rapsyn.},
  author={Zichun Wang and Askale Mathias and Medha Gautam and Zach W. Hall},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={19 6},
Although the metabolic half-life of muscle endplate acetylcholine receptor (AChR) changes during development and after denervation in the adult, little is known about the molecular mechanisms that influence receptor stability. We have investigated the effect on AChR turnover of its interaction with rapsyn, a 43 kDa peripheral membrane protein that is closely associated with the AChR in muscle cells and is required for its clustering at endplates. Both in transfected COS cells and in cultured… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Receptor-associated proteins and synaptic plasticity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2009


Publications referenced by this paper.
Showing 1-10 of 77 references

Surface receptor expression determinants: mechanism

KT Dineley, JW Patrick
Soc Neurosci Abstr • 1998
View 5 Excerpts
Highly Influenced

Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor.

Molecular and cellular neurosciences • 1997
View 2 Excerpts
Highly Influenced

Assembly of the postsynaptic apparatus.

Current opinion in neurobiology • 1995
View 6 Excerpts
Highly Influenced

The submembrane machinery for nicotinic acetylcholine receptor clustering

The Journal of cell biology • 1991
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…