Metabolic stability and epigenesis in randomly constructed genetic nets.

@article{Kauffman1969MetabolicSA,
  title={Metabolic stability and epigenesis in randomly constructed genetic nets.},
  author={S. Kauffman},
  journal={Journal of theoretical biology},
  year={1969},
  volume={22 3},
  pages={
          437-67
        }
}
  • S. Kauffman
  • Published 1969
  • Biology, Medicine
  • Journal of theoretical biology
Abstract Proto-organisms probably were randomly aggregated nets of chemical reactions. The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”. The results suggest that, if each “gene” is directly affected by two or three other “genes”, then such random nets: behave with great order and stability; undergo behavior… Expand
3,760 Citations
The regulatory network of E. coli metabolism as a Boolean dynamical system exhibits both homeostasis and flexibility of response
  • 89
  • Highly Influenced
  • PDF
Evolution of discrete gene regulatory models
  • 11
  • PDF
Cell phenotypes as macrostates of the GRN dynamics.
  • 1
Genetic Regulatory Network Models of Biological Clocks: Evolutionary History Matters
  • 22
Eukaryotic cells are dynamically ordered or critical but not chaotic.
  • 214
  • PDF
Dynamics of Boolean networks controlled by biologically meaningful functions.
  • 106
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Sequential DNA replication and the control of differences in gene activity between sister chromatids--a possible factor in cell differentiation.
  • S. Kauffman
  • Biology, Medicine
  • Journal of theoretical biology
  • 1967
  • 19
A model for binary logic in biochemical systems.
  • 17
Functional analysis of chemical systems in vivo using a logical circuit equivalent. II. The idea of a molecular automation.
  • M. Sugita
  • Mathematics, Medicine
  • Journal of theoretical biology
  • 1963
  • 85
Biochemical Aspects of Genetics
  • 25
  • PDF
Synchrony of nuclear replication in individual hyphae of Aspergillus nidulans.
  • 84
  • Highly Influential
  • PDF
GROWTH
  • 3,300
  • PDF
ASPECTS OF THE AGING OF THE AVIAN (NUCLEATED) RED BLOOD CELL IN VIVO.
  • 4
Nucleic Acids
  • 413
  • Highly Influential
  • PDF
Molecular Biology of the Gene
  • 768
...
1
2
3
4
...