Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

  title={Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota},
  author={L. Hoyles and M. L. Jim{\'e}nez-Pranteda and Julien Chilloux and François Brial and A. Myridakis and T. Aranias and C. Magnan and G. Gibson and J. Sanderson and J. Nicholson and D. Gauguier and A. McCartney and M. Dumas},
The dietary methylamines choline, carnitine and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA). However, little is known about the use of trimethylamine N-oxide (TMAO) by this consortium of microbes. A feeding study using deuterated TMAO in C57BL6/J mice demonstrated microbial conversion of TMAO to TMA, with uptake of TMA into the bloodstream and its conversion to TMAO. Antibiotic-treated mice lacked microbial activity… Expand
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Blood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine
The results showed that the microbiota in the small intestine generated the PC breakdown product TMA, and the resulting TMAO was suppressed by topical-acting antibiotics or when PC was presented in an intestinally delayed release preparation. Expand
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk. Expand
Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects.
A role for TMAO and gut microbiota in transmitting heightened thrombosis potential in vivo was supported by both direct T MAO infusion and microbial transplantation studies. Expand
Disclosure of the metabolic retroversion of trimethylamine N‐oxide in humans: A pharmacogenetic approach
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The metabolic fate of isotopically labeled trimethylamine-N-oxide (TMAO) in humans.
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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
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Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
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