Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

@article{Hoyles2017MetabolicRO,
  title={Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota},
  author={L. Hoyles and M. L. Jim{\'e}nez-Pranteda and Julien Chilloux and François Brial and A. Myridakis and T. Aranias and C. Magnan and G. Gibson and J. Sanderson and J. Nicholson and D. Gauguier and A. McCartney and M. Dumas},
  journal={bioRxiv},
  year={2017}
}
The dietary methylamines choline, carnitine and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA). However, little is known about the use of trimethylamine N-oxide (TMAO) by this consortium of microbes. A feeding study using deuterated TMAO in C57BL6/J mice demonstrated microbial conversion of TMAO to TMA, with uptake of TMA into the bloodstream and its conversion to TMAO. Antibiotic-treated mice lacked microbial activity… Expand
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