Metabolic reprogramming of the tumour microenvironment.

@article{Xing2015MetabolicRO,
  title={Metabolic reprogramming of the tumour microenvironment.},
  author={Yazhi Xing and Shiming Zhao and Binhua Peter Zhou and Jun Mi},
  journal={The FEBS journal},
  year={2015},
  volume={282 20},
  pages={
          3892-8
        }
}
Tumour cells, stromal cells and the stroma comprise the tumour microenvironment. The metabolism of both tumour cells and several types of tumour stromal cells, such as cancer-associated fibroblasts and tumour-associated macrophages, is reprogrammed. Current studies have found that stromal cells promote tumour progression and metastasis, through not only the paracrine secretion of cytokines or chemokines, but also intermediate metabolites. Here, we summarize the latest insights into the… CONTINUE READING

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