Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.

@article{Freemerman2014MetabolicRO,
  title={Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.},
  author={Alex J. Freemerman and Amy Rose Johnson and Gina N Sacks and J Justin Milner and Erin L. Kirk and Melissa A. Troester and Andrew N. Macintyre and Pankuri Goraksha-Hicks and Jeffery C Rathmell and Liza Makowski},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 11},
  pages={
          7884-96
        }
}
Glucose is a critical component in the proinflammatory response of macrophages (MΦs). However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating subsequent glucose metabolism in the inflammatory response are not well understood. Because MΦs contribute to obesity-induced inflammation, it is important to understand how substrate metabolism may alter inflammatory function. We report that GLUT1 (SLC2A1) is the primary rate-limiting glucose transporter on proinflammatory… CONTINUE READING
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