Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

@article{Guido2012MetabolicRO,
  title={Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.},
  author={Carmela Guido and Diana Whitaker-Menezes and Claudia Capparelli and Renee M Balliet and Zhao Lin and Richard G. Pestell and Anthony Howell and Saveria Aquila and Sebastiano And{\'o} and Ubaldo e. Martinez-outschoorn and Federica Sotgia and Michael Phillip Lisanti},
  journal={Cell cycle},
  year={2012},
  volume={11 16},
  pages={3019-35}
}
We have previously shown that a loss of stromal Cav-1 is a biomarker of poor prognosis in breast cancers. Mechanistically, a loss of Cav-1 induces the metabolic reprogramming of stromal cells, with increased autophagy/mitophagy, mitochondrial dysfunction and aerobic glycolysis. As a consequence, Cav-1-low CAFs generate nutrients (such as L-lactate) and chemical building blocks that fuel mitochondrial metabolism and the anabolic growth of adjacent breast cancer cells. It is also known that a… CONTINUE READING
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