Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions.

@article{Agnihotri2016MetabolicRI,
  title={Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions.},
  author={Sameer Agnihotri and Gelareh Mohammed Zadeh},
  journal={Neuro-oncology},
  year={2016},
  volume={18 2},
  pages={160-72}
}
A defining hallmark of glioblastoma is altered tumor metabolism. The metabolic shift towards aerobic glycolysis with reprogramming of mitochondrial oxidative phosphorylation, regardless of oxygen availability, is a phenomenon known as the Warburg effect. In addition to the Warburg effect, glioblastoma tumor cells also utilize the tricarboxylic acid cycle/oxidative phosphorylation in a different capacity than normal tissue. Altered metabolic enzymes and their metabolites are oncogenic and not… CONTINUE READING
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