Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade.

@article{Lue2017MetabolicRE,
  title={Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade.},
  author={Hui-Wen Lue and Jennifer Podolak and Kevin Kolahi and Larry C Cheng and Soumya Alige Mahabala Rao and Devin Garg and Chang-Hui Xue and Juha K. Rantala and Jeffrey W. Tyner and Kent L. Thornburg and Ann Martinez-Acevedo and Jen Liu and Christopher L Amling and Charles Truillet and Sharon M Louie and Kimberly E Anderson and Michael J Evans and Valerie B. O'Donnell and Daniel K Nomura and Justin M Drake and Anna M. Ritz and George V Thomas},
  journal={Genes & development},
  year={2017},
  volume={31 20},
  pages={
          2067-2084
        }
}
There is limited knowledge about the metabolic reprogramming induced by cancer therapies and how this contributes to therapeutic resistance. Here we show that although inhibition of PI3K-AKT-mTOR signaling markedly decreased glycolysis and restrained tumor growth, these signaling and metabolic restrictions triggered autophagy, which supplied the metabolites required for the maintenance of mitochondrial respiration and redox homeostasis. Specifically, we found that survival of cancer cells was… CONTINUE READING
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