Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.

@article{Chiavarina2012MetabolicRA,
  title={Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.},
  author={Barbara Chiavarina and Ubaldo e. Martinez-outschoorn and Diana Whitaker-Menezes and Anthony Howell and Herbert B Tanowitz and Richard G. Pestell and Federica Sotgia and Michael Phillip Lisanti},
  journal={Cell cycle},
  year={2012},
  volume={11 17},
  pages={3280-9}
}
Hypoxia-inducible factor (HIF) 1α and 2α are transcription factors responsible for the cellular response to hypoxia. The functional roles of HIF1α and HIF2α in cancer are distinct and vary among different tumor types. The aim of this study was to evaluate the compartment-specific role(s) of HIF1α and HIF2α in breast cancer. To this end, immortalized human fibroblasts and MDA-MB-231 breast cancer cells carrying constitutively active HIF1α or HIF2α mutants were analyzed with respect to their… CONTINUE READING
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