Metabolic reprogramming and tolerance during sepsis-induced AKI

  title={Metabolic reprogramming and tolerance during sepsis-induced AKI},
  author={Hernando Gomez and John A. Kellum and Claudio Ronco},
  journal={Nature Reviews Nephrology},
The host defence against infection is an adaptive response in which several mechanisms are deployed to decrease the pathogen load, limit tissue injury and restore homeostasis. In the past few years new evidence has suggested that the ability of the immune system to limit the microbial burden — termed resistance — might not be the only defence mechanism. In fact, the capacity of the host to decrease its own susceptibility to inflammation- induced tissue damage — termed tolerance — might be as… CONTINUE READING