Metabolic reprogramming: the emerging concept and associated therapeutic strategies

@inproceedings{Yoshida2015MetabolicRT,
  title={Metabolic reprogramming: the emerging concept and associated therapeutic strategies},
  author={Go J Yoshida},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2015}
}
Tumor tissue is composed of cancer cells and surrounding stromal cells with diverse genetic/epigenetic backgrounds, a situation known as intra-tumoral heterogeneity. Cancer cells are surrounded by a totally different microenvironment than that of normal cells; consequently, tumor cells must exhibit rapidly adaptive responses to hypoxia and hypo-nutrient conditions. This phenomenon of changes of tumor cellular bioenergetics, called "metabolic reprogramming", has been recognized as one of 10… CONTINUE READING
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