Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?

  title={Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?},
  author={M W T van Bilsen and Pascal J H Smeets and Andries J. Gilde and Ger J. van der Vusse},
  journal={Cardiovascular research},
  volume={61 2},
It has been postulated that the failing heart suffers from chronic energy starvation, and that derangements in cardiac energy conversion are accessory to the progressive nature of this disease. The molecular mechanisms driving this 'metabolic remodelling' process and their significance for the development of cardiac failure are still open to discussion. Next to changes in mitochondrial function, the hypertrophied heart is characterized by a marked shift in substrate preference away from fatty… CONTINUE READING

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Peroxisome proliferator-activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle

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