Metabolic remodelling of the failing heart: beneficial or detrimental?

  title={Metabolic remodelling of the failing heart: beneficial or detrimental?},
  author={Marc van Bilsen and Frans A. van Nieuwenhoven and Ger J. van der Vusse},
  journal={Cardiovascular research},
  volume={81 3},
The failing heart is characterized by alterations in energy metabolism, including mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially compensated by an increase in glucose utilization. Together, these changes lead to an impaired capacity to convert chemical energy into mechanical work. This has led to the concept that supporting cardiac energy conversion through metabolic interventions provides an important adjuvant therapy for heart failure. The… CONTINUE READING


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