Metabolic relevance for N-hydroxy l-arginine reduction in estrogen-negative breast cancer cells

@article{Mohan2018MetabolicRF,
  title={Metabolic relevance for N-hydroxy l-arginine reduction in estrogen-negative breast cancer cells},
  author={Srinidi Mohan and Seema Patel and Ian Greenstein and Cathy Y Ng and Kelly G. Frazier and Giang V. Nguyen and Lisa Lynn Harding and David R. Barlow},
  journal={Amino Acids},
  year={2018},
  volume={50},
  pages={1629-1636}
}
We had shown N w-hydroxy-l-arginine (NOHA) as a promising blood-based biomarker for estrogen-receptor-negative (ER − ) breast cancer (BC) that differentiates ER − BC based on grade and molecular phenotype. In this in vitro study, we assessed the metabolic relevance for ER− BC-specific NOHA modulation and correlated them with NOHA regulatory responses. This study aids future NOHA clinical utility in ER− BC diagnosis and therapy management and would prove useful for potential drug discovery and… CONTINUE READING
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