Metabolic regulation via intracellular pH.

  title={Metabolic regulation via intracellular pH.},
  author={William B Busa and Richard Nuccitelli},
  journal={The American journal of physiology},
  volume={246 4 Pt 2},
Despite earlier notions that intracellular pH (pHi) was invariant with time, recent studies have documented pHi changes of from 0.1 to 1.6 U during metabolic and developmental transitions in a variety of cells. Here we review the evidence for pHi-mediated regulation of gamete activation, cellular dormancy, the cell cycle, and stimulus-response coupling. Intracellular Ca2+ level changes also accompany many of these same transitions, and mounting evidence suggests that pHi and Ca2+ changes can be… CONTINUE READING
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