Metabolic regulation of organelle homeostasis in lupus T cells.

@article{Caza2012MetabolicRO,
  title={Metabolic regulation of organelle homeostasis in lupus T cells.},
  author={Tiffany N. Caza and Gergely Talaber and Andr{\'a}s Perl},
  journal={Clinical immunology},
  year={2012},
  volume={144 3},
  pages={
          200-13
        }
}
Abnormal T-cell signaling and activation are characteristic features in systemic lupus erythematosus (SLE). Lupus T cells are shifted toward an over-activated state, important signaling pathways are rewired, and signaling molecules are replaced. Disturbances in metabolic and organelle homeostasis, importantly within the mitochondrial, endosomal, and autophagosomal compartments, underlie the changes in signal transduction. Mitochondrial hyperpolarization, enhanced endosomal recycling, and… CONTINUE READING
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