Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine.

@article{Rudolph2007MetabolicRI,
  title={Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine.},
  author={Michael C Rudolph and James L McManaman and Tzulip Phang and Tanya L. Russell and Douglas J. Kominsky and Natalie J. Serkova and Torsten Stein and Steven M. Anderson and Margaret C. Neville},
  journal={Physiological genomics},
  year={2007},
  volume={28 3},
  pages={323-36}
}
The mammary gland of the lactating mouse synthesizes and secretes milk lipid equivalent to its entire body weight in a single 20-day lactation cycle, making it one of the most active lipid synthetic organs known. We test the hypothesis that multiple control points and potential regulatory mechanisms regulate milk lipid synthesis at the level of gene expression. The mammary transcriptome of 130 genes involved in glucose metabolism was examined at late pregnancy and early lactation, utilizing… CONTINUE READING
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