Metabolic regulation and function of glutathione peroxidase-1.

@article{Lei2007MetabolicRA,
  title={Metabolic regulation and function of glutathione peroxidase-1.},
  author={Xin Gen Lei and W H Cheng and James P. McClung},
  journal={Annual review of nutrition},
  year={2007},
  volume={27},
  pages={41-61}
}
Glutathione peroxidase-1 (GPX1) represents the first identified mammalian selenoprotein, and our understanding in the metabolic regulation and function of this abundant selenoenzyme has greatly advanced during the past decade. Selenocysteine insertion sequence-associating factors, adenosine, and Abl and Arg tyrosine kinases are potent, Se-independent regulators of GPX1 gene, protein, and activity. Overwhelming evidences have been generated using the GPX1 knockout and transgenic mice for the in… CONTINUE READING
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