Metabolic regulation and function of glutathione peroxidase-1.

  title={Metabolic regulation and function of glutathione peroxidase-1.},
  author={Xin Gen Lei and W H Cheng and James P. McClung},
  journal={Annual review of nutrition},
Glutathione peroxidase-1 (GPX1) represents the first identified mammalian selenoprotein, and our understanding in the metabolic regulation and function of this abundant selenoenzyme has greatly advanced during the past decade. Selenocysteine insertion sequence-associating factors, adenosine, and Abl and Arg tyrosine kinases are potent, Se-independent regulators of GPX1 gene, protein, and activity. Overwhelming evidences have been generated using the GPX1 knockout and transgenic mice for the in… CONTINUE READING
80 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 80 extracted citations

Similar Papers

Loading similar papers…