Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference.

@article{Zaitsu2014MetabolicPO,
  title={Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference.},
  author={Kei Zaitsu and Izuru Miyawaki and Kiyoko Bando and Hiroshi Horie and Noriaki Shima and Munehiro Katagi and Michiaki Tatsuno and Takeshi Bamba and Takako Sato and Akira Ishii and Hitoshi Tsuchihashi and Koichi Suzuki and Eiichiro Fukusaki},
  journal={Analytical and bioanalytical chemistry},
  year={2014},
  volume={406 5},
  pages={1339-54}
}
The metabolic profiles of urine and blood plasma in drug-addicted rat models based on morphine (MOR), methamphetamine (MA), and cocaine (COC)-induced conditioned place preference (CPP) were investigated. Rewarding effects induced by each drug were assessed by use of the CPP model. A mass spectrometry (MS)-based metabolomics approach was applied to urine and plasma of MOR, MA, and COC-addicted rats. In total, 57 metabolites in plasma and 70 metabolites in urine were identified by gas… CONTINUE READING