Metabolic profiling of the hepatotoxicity and nephrotoxicity of Ginkgolic acids in rats using ultra-performance liquid chromatography-high-definition mass spectrometry.

@article{Qian2017MetabolicPO,
  title={Metabolic profiling of the hepatotoxicity and nephrotoxicity of Ginkgolic acids in rats using ultra-performance liquid chromatography-high-definition mass spectrometry.},
  author={Yiyun Qian and Yunru Peng and Erxin Shang and M. Zhao and L. Yan and Zhenhua Zhu and Jinhua Tao and Shulan Su and S. Guo and J. Duan},
  journal={Chemico-biological interactions},
  year={2017},
  volume={273},
  pages={
          11-17
        }
}
  • Yiyun Qian, Yunru Peng, +7 authors J. Duan
  • Published 2017
  • Medicine, Chemistry
  • Chemico-biological interactions
  • Ginkgolic acids (GAs) are thought to be the potentially hazardous constituents corresponding to the toxic side effects of Ginkgo products. In this study, toxicological and metabolomics studies of GAs were carried out by ultra-performance liquid chromatography-high-definition mass spectrometry (UPLC-HDMS). Significant changes in serum clinical chemistry were observed in the both low (100 mg/kg) and high (900 mg/kg) doses. Especially the serum enzyme of ALT, AST, LDH, and CK decreased in treated… CONTINUE READING
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