Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies.

@article{Somashekar2011MetabolicPO,
  title={Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies.},
  author={Bagganahalli S Somashekar and Anita G. Amin and Christopher D. Rithner and Jolynn L Troudt and Randall J Basaraba and Angelo Izzo and Dean C Crick and Delphi Chatterjee},
  journal={Journal of proteome research},
  year={2011},
  volume={10 9},
  pages={4186-95}
}
A crucial and distinctive feature of tuberculosis infection is that Mycobacterium tuberculosis (Mtb) resides in granulomatous lesion at various stages of disease development and necrosis, an aspect that is little understood. We used a novel approach, applying high resolution magic angle spinning nuclear magnetic resonance spectroscopy (HRMAS NMR) directly to infected tissues, allowing us to study the development of tuberculosis granulomas in guinea pigs in an untargeted manner. Significant up… CONTINUE READING