Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.

@article{Loo2009MetabolicPA,
  title={Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.},
  author={Ruey Leng Loo and Muireann Coen and Timothy M. D. Ebbels and Olivier Cloarec and Elaine C Maibaum and Magda Bictash and Ivan Yap and Paul Elliott and Jeremiah Stamler and Jeremy K. Nicholson and Elaine Holmes},
  journal={Analytical chemistry},
  year={2009},
  volume={81 13},
  pages={5119-29}
}
The application of a (1)H nuclear magnetic resonance (NMR) spectroscopy-based screening method for determining the use of two widely available analgesics (acetaminophen and ibuprofen) in epidemiologic studies has been investigated. We used samples and data from the cross-sectional INTERMAP Study involving participants from Japan (n = 1145), China (n = 839), U.K. (n = 501), and the U.S. (n = 2195). An orthogonal projection to latent structures discriminant analysis (OPLS-DA) algorithm with an… CONTINUE READING

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