Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.

@article{Balani1997MetabolicPO,
  title={Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.},
  author={Suresh K. Balani and X Xu and Vijaya S. Pratha and Michael A. Koss and Raju D. Amin and Christelle Dufresne and R. R. Miller and Byron H. Arison and George A. Doss and M Chiba and Arnold James Freeman and Sherry D. Holland and Jules I. Schwartz and Kenneth C. Lasseter and Barry J. Gertz and Jon I. Isenberg and John Douglas Rogers and Jiunn Huei Lin and Thomas A Baillie},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1997},
  volume={25 11},
  pages={
          1282-7
        }
}
Montelukast sodium [1-([(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl)cyclopropylacetic acid sodium salt] (MK-476, Singulair) is a potent and selective antagonist of the cysteinyl leukotriene (Cys-LT1) receptor and is under investigation for the treatment of bronchial asthma. To assess the metabolism and excretion of montelukast, six healthy subjects received single oral doses of 102 mg of [14C]montelukast, and the urine and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Nahrwold : The biliary system

L. D.
  • Pharm . Res .
  • 1996

Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and Females

Haiyung Cheng, Jonathan A. Leff, +7 authors G. Somers
  • Pharmaceutical Research
  • 1996
VIEW 2 EXCERPTS

Van der Straeten : The effect of aerosalized SK & F104353Z 2 on bronchoconstriction induced by inhaled leukotriene D 4 in asthmatics

J. C. Kips, R. A. Pauwels, E. M.
  • Med . Lett . Drugs Ther .
  • 1996