Metabolic profile of glyburide in human liver microsomes using LC-DAD-Q-TRAP-MS/MS.

Abstract

The sulfonylurea urea drug glyburide (glibenclamide) is widely used for the treatment of diabetes milletus and gestational diabetes. In previous studies monohydroxylated metabolites were identified and characterized for glyburide in different species, but the metabolite owing to the loss of cyclohexyl ring was identified only in mouse. Glyburide upon… (More)
DOI: 10.1002/bmc.2830

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