Metabolic profile of Rhizoma coptidis in human plasma determined using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry.

@article{Zhang2018MetabolicPO,
  title={Metabolic profile of Rhizoma coptidis in human plasma determined using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry.},
  author={Qing-shan Zhang and Gao-Wa Wang and Zhi-qiang Han and Xiang-Mei Chen and Risu Na and Haburi Jin and Ping Li and Renbatu Bu},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2018},
  volume={32 1},
  pages={
          63-73
        }
}
RATIONALE Rhizoma coptidis extract and its alkaloids show various pharmacological activities, but its metabolic profile in human plasma has not been thoroughly investigated. In the present research, the metabolism of Rhizoma coptidis at a clinical dose (5 g/60 kg/day) was systematically analyzed to determine its biotransformation processes in human plasma. METHODS In this research, the metabolites of Rhizoma coptidis in human plasma after oral administration of Rhizoma coptidis extract at a… CONTINUE READING
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Metabolism of Rhizoma coptidis in Human Urine by Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry

  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2018
VIEW 6 EXCERPTS
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