Metabolic products of microorganisms. 243. Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger.

@article{Grote1988MetabolicPO,
  title={Metabolic products of microorganisms. 243. Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger.},
  author={Reinhard Grote and Yao-zu Chen and Axel Zeeck and Zhao Xu Chen and Hans Z{\"a}hner and P Mischnick-L{\"u}bbecke and Wilfried A. K{\"o}nig},
  journal={The Journal of antibiotics},
  year={1988},
  volume={41 5},
  pages={595-601}
}
Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger sp. griseofuscus (strain Tü 2557), was detected in a selective screening against Mucor hiemalis (Tü 179/180). The amino acid side chain of 1 can be seen as L-ornithine, whose gamma-nitrogen atom is part of a pyridazine ring building a quaternary ammonium system. The structure… CONTINUE READING