Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse.

@article{Shaw1994MetabolicPO,
  title={Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse.},
  author={Leslie M. Shaw and Heather S Bonner and Devon Brown},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1994},
  volume={22 6},
  pages={895-902}
}
This study investigated the metabolism of the radio- and chemoprotector compound, WR-2721 [amifostine; s-2-(3- aminopropylamino)ethylphosphorothioate], in the Balb/c mouse. The latter was selected for these studies because considerable radiation protection data have been published for this mouse strain using the WR-2721 dose, route of administration, and… CONTINUE READING