Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP).
- BiologyEcotoxicology and environmental safety
Activation of amino acid metabolic program in response to impaired glycolysis in cardiac HIF1 deficient mice
It is found that deletion of Hif1a leads to impaired embryonic glycolysis without influencing cardiomyocyte proliferation and results in an increased mitochondrial number, activation of a transient amino acid response and upregulation of HIF2α and ATF4 by E12.5.
Metabolic reprogramming from glycolysis to amino acid utilization in cardiac HIF1α deficient mice
The results reveal the metabolic flexibility of the embryonic heart at early stages of development, showing the capacity of the myocardium to adapt its energy source to satisfy the energetic and building blocks demands to achieve normal cardiac growth and function.
Metabolic flux analyses to assess the differentiation of adult cardiac progenitors after fatty acid supplementation
- BiologyStem cell research
1H NMR based Metabolic Signatures in Liver and Brain in Rat Model of Hepatic Encephalopathy.
- BiologyJournal of proteome research
Assessment of metabolic alterations in brain and liver using nuclear magnetic resonance spectroscopy and subsequent multivariate analyses suggests impairment in metabolic pathways such as tricarboxylic acid (TCA) cycle, glycolysis and ketogenesis in liver and brain of animals with HE.
1H NMR Based Serum Metabolic Profiling Reveals Differentiating Biomarkers in Patients with Diabetes and Diabetes Comorbidity
- Medicine, Biology
The 1H NMR metabolomics may prove a promising technique to differentiate and predict diabetes and its comorbidities on their onset or progression by determining the altered levels of the metabolites in serum.
1H NMR based serum metabolic profiling reveals differentiating biomarkers in patients with diabetes and diabetes-related complication.
- Medicine, BiologyDiabetes & metabolic syndrome
Microphysiological stem cell models of the human heart
- BiologyMaterials today. Bio
Multicellularity in the Cardiovascular System
- Frontiers Research Topics
Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders
- Psychology, BiologyThe Australian and New Zealand journal of psychiatry
It could be hypothesised that the common changes in gene expression in major depression and bipolar disorder are involved in the genesis of symptoms common to both disorders.
SHOWING 1-5 OF 5 REFERENCES
Myocardial substrate metabolism in the normal and failing heart.
- Biology, MedicinePhysiological reviews
This review discusses the metabolic changes that occur in chronic heart failure, with emphasis on the mechanisms that regulate the changes in the expression of metabolic genes and the function of metabolic pathways and the consequences of these metabolic changes on cardiac function.
The Randle cycle revisited: a new head for an old hat.
- BiologyAmerican journal of physiology. Endocrinology and metabolism
The known short- and long-term mechanisms involved in the control of glucose and fatty acid utilization at the cytoplasmic and mitochondrial level in mammalian muscle and liver under normal and pathophysiological conditions are reviewed.
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.