Metabolic pathways and abnormalities

@article{Evans2016MetabolicPA,
  title={Metabolic pathways and abnormalities},
  author={Rhys D. Evans and Lisa C. Heather},
  journal={Surgery (oxford)},
  year={2016},
  volume={34},
  pages={266-272}
}
Activation of amino acid metabolic program in response to impaired glycolysis in cardiac HIF1 deficient mice
TLDR
It is found that deletion of Hif1a leads to impaired embryonic glycolysis without influencing cardiomyocyte proliferation and results in an increased mitochondrial number, activation of a transient amino acid response and upregulation of HIF2α and ATF4 by E12.5.
Metabolic reprogramming from glycolysis to amino acid utilization in cardiac HIF1α deficient mice
TLDR
The results reveal the metabolic flexibility of the embryonic heart at early stages of development, showing the capacity of the myocardium to adapt its energy source to satisfy the energetic and building blocks demands to achieve normal cardiac growth and function.
1H NMR based Metabolic Signatures in Liver and Brain in Rat Model of Hepatic Encephalopathy.
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Assessment of metabolic alterations in brain and liver using nuclear magnetic resonance spectroscopy and subsequent multivariate analyses suggests impairment in metabolic pathways such as tricarboxylic acid (TCA) cycle, glycolysis and ketogenesis in liver and brain of animals with HE.
1H NMR Based Serum Metabolic Profiling Reveals Differentiating Biomarkers in Patients with Diabetes and Diabetes Comorbidity
TLDR
The 1H NMR metabolomics may prove a promising technique to differentiate and predict diabetes and its comorbidities on their onset or progression by determining the altered levels of the metabolites in serum.
Microphysiological stem cell models of the human heart
Multicellularity in the Cardiovascular System
Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders
TLDR
It could be hypothesised that the common changes in gene expression in major depression and bipolar disorder are involved in the genesis of symptoms common to both disorders.
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The known short- and long-term mechanisms involved in the control of glucose and fatty acid utilization at the cytoplasmic and mitochondrial level in mammalian muscle and liver under normal and pathophysiological conditions are reviewed.
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