Metabolic pathway alterations that support cell proliferation.

  title={Metabolic pathway alterations that support cell proliferation.},
  author={Matthew G Vander Heiden and Sophia Y Lunt and Talya L. Dayton and Brian P. Fiske and William J. Israelsen and Katherine R. Mattaini and Natalie I Vokes and Gregory Stephanopoulos and Lewis C. Cantley and Christian M. Metallo and Jason W. Locasale},
  journal={Cold Spring Harbor symposia on quantitative biology},
Proliferating cells adapt metabolism to support the conversion of available nutrients into biomass. How cell metabolism is regulated to balance the production of ATP, metabolite building blocks, and reducing equivalents remains uncertain. Proliferative metabolism often involves an increased rate of glycolysis. A key regulated step in glycolysis is catalyzed by pyruvate kinase to convert phosphoenolpyruvate (PEP) to pyruvate. Surprisingly, there is strong selection for expression of the less… CONTINUE READING
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