Metabolic network structure determines key aspects of functionality and regulation

@article{Stelling2002MetabolicNS,
  title={Metabolic network structure determines key aspects of functionality and regulation},
  author={J{\"o}rg Stelling and Steffen Klamt and Katja Bettenbrock and Stefan Schuster and Ernst Dieter Gilles},
  journal={Nature},
  year={2002},
  volume={420},
  pages={190-193}
}
The relationship between structure, function and regulation in complex cellular networks is a still largely open question. Systems biology aims to explain this relationship by combining experimental and theoretical approaches. Current theories have various strengths and shortcomings in providing an integrated, predictive description of cellular networks. Specifically, dynamic mathematical modelling of large-scale networks meets difficulties because the necessary mechanistic detail and kinetic… Expand
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