Carbon monoxide: a vital signalling molecule and potent toxin in the myocardium.
- BiologyJournal of molecular and cellular cardiology
Contaminación por monóxido de carbono: un problema de salud ambiental
Lack of memory, attention, concentration and Parkinson-type altered movement are the neuropsychological changes most frequently associated with chronic exposure to low levels of carbon monoxide and carboxyhaemoglobin.
Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovascular system at doses corresponding to tobacco smoking.
- Medicine, BiologyToxicology
Modulation of ion channels and transporters by carbon monoxide: causes for concern?
- BiologyFront. Physio.
Modulation of some channels by CO may contribute to its beneficial actions, yet the sensitivity of other channels to CO may account, at least in part, for some of its deleterious actions (summarized in Figure Figure1).
Developing drug molecules for therapy with carbon monoxide.
- BiologyChemical Society reviews
This tutorial review summarises the biological and chemical behaviour of CO, the current status ofCO-RM development, and derives principles for the creation of the next generation of CO-RMs for clinical applications in humans.
Proteins as biomarkers of carbon monoxide neurotoxicity
- Biology, MedicineInhalation toxicology
CO poisoning appears to be associated with an elevated level of Tau and S100B proteins in the serum of patients who had suffered a loss of consciousness, and it is shown that Tau protein is a more sensitive biomarker than S 100B protein for the earlier stage of neurotoxic effects of CO intoxication.
The effects of amifostine and dexamethasone on brain tissue lipid peroxidation during oxygen treatment of carbon monoxide-poisoned rats
- ChemistryAdvances in therapy
Blood gas analysis, carboxy-hemoglobin determination, brain tissue lipid peroxidation, and glutathione peroxidase, superoxide dismutase (SOD), lactate dehydrogenase (LDH), and creatine kinase (CK) activities were evaluated.
Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications.
- Biology, MedicineCurrent medicinal chemistry
The potential of RBC and Hb-based artificial oxygen carriers as CO carriers based on the currently available literature evidence for their use in pharmaceutical therapy against intractable disorders is overview.
SHOWING 1-10 OF 54 REFERENCES
Carbon monoxide poisoning--a public health perspective.
Anthropogenic Emissions of Carbon Monoxide
- Environmental ScienceReviews on environmental health
Control measures for motor vehicles and indoor heating appliances are suggested, and monitoring methods are considered in relation to air quality standards and guidelines.
Carbon monoxide poisoning: a review for clinicians.
- MedicineThe Journal of emergency medicine
Carbon monoxide and cardiovascular disease: an analysis of the weight of evidence.
- Environmental ScienceRegulatory toxicology and pharmacology : RTP
It is concluded that if ETS plays a role in the etiology of cardiovascular disease, it is most likely not mediated through carbon monoxide.
Oxidative damage on lymphocyte membranes is increased in patients suffering from acute carbon monoxide poisoning.
- Medicine, BiologyToxicology letters
Cardiovascular disease hospitalization and ambient levels of carbon monoxide.
- MedicineJournal of toxicology and environmental health. Part A
Assessment of the association between hospital admissions for cardiovascular system illnesses and the ambient levels of CO in the Reno-Sparks, NV, area over a 6-yr period suggests a positive correlation between ambient CO levels and hospital admission for CV diseases.
The effect of phenobarbital and 3-methylcholanthrene treatment on carbon tetrachloride-stimulated heme degradation and carbon monoxide expiration in vivo
Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning.
- Biology, ChemistryJournal of applied physiology
The data indicate that nitric oxide-derived oxidants are involved in CO-mediated oxidative stress within the vascular compartment and that elevations of several compounds may be useful for identifying exposures to CO likely to precipitate brain injury.
Dehydrogenase conversion to oxidase and lipid peroxidation in brain after carbon monoxide poisoning.
- Biology, ChemistryJournal of applied physiology
Results are consistent with the view that CO-mediated brain injury is a type of postischemic reperfusion phenomenon and indicate that xanthine oxidase-derived reactive oxygen species are responsible for lipid peroxidation.
Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.
- Biology, ChemistryThe Journal of clinical investigation
It is proposed that PROS generated in the brain after CO hypoxia originate primarily from mitochondria, and may contribute to CO-mediated neuronal damage during reoxygenation after severe CO intoxication.