Metabolic memory for vascular disease in diabetes.

  title={Metabolic memory for vascular disease in diabetes.},
  author={Pablo Aschner and Alvaro J Ru{\'i}z},
  journal={Diabetes technology & therapeutics},
  volume={14 Suppl 1},
Although the terms "metabolic memory" and "legacy effect" have been used to describe the prolonged benefits of good blood glucose control, the former is now recognized as a phenomenon related to the prolonged harm produced mainly by hyperglycemia. At least three randomized clinical trials (Diabetes Control and Complications Trial in type 1 diabetes, United Kingdom Prospective Diabetes Study and Steno-2 in type 2 diabetes) have demonstrated that patients treated intensively for a period of time… CONTINUE READING
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