Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response.

@article{Barrett2003MetabolicMO,
  title={Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response.},
  author={Douglas W. Barrett and Jason Shumake and Dirk Jones and F. Gonzalez-Lima},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 13},
  pages={5740-9}
}
Metabolic mapping with fluorodeoxyglucose (FDG), a radiolabeled glucose analog, was used to assess regional activity changes in the mouse brain that result from extinction of a conditioned emotional response (CER). In the extinction group, Pavlovian tone-foot shock conditioning, followed by repeated tone-alone presentations, resulted in the reduction of the CER (freezing behavior). A second group underwent CER acquisition alone (nonextinction group), and a third group showed no CER after… CONTINUE READING

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